![]() Therefore, timely identification and management of these factors are very important for preventing and reducing the occurrence and severity of AECOPD. These factors may affect the condition and prognosis of COPD patients through different mechanisms, such as increasing inflammation in the airways and lungs, damaging airway epithelial cells, stimulating airway smooth muscle contraction, reducing lung function and immunity, increasing cardiovascular risk and systemic inflammation levels, etc. Some factors that cause AECOPD have been identified, including respiratory tract infections, smoking, environmental pollution, prior exacerbations, non-adherence to treatment and associated comorbidities. A number of aggravating factors have been identified during the disease process, these factors can culminate in acute exacerbations of COPD (AECOPD). As a chronic condition, COPD has been associated with significant morbidity and diminished quality of life for the affected individuals. The development of COPD has been linked to numerous risk factors, including tobacco smoke, air pollution, occupational exposures, and genetic predisposition, which can contribute to both onset and exacerbation of the disease. ![]() COPD presents a considerable global health challenge as it is the third leading cause of mortality worldwide and incurs significant healthcare costs for global populations. Clinicians should weigh the benefits and risks of each mode of mechanical ventilation when selecting a ventilation strategy.Ĭhronic obstructive pulmonary disease (COPD) is a progressive and debilitating respiratory condition which is characterized by permanent airflow restriction and persistent inflammation in the lungs. However, further large-scale studies are necessary to confirm these findings and identify the best ventilation approach for patients experiencing an acute COPD exacerbation. The results showed that both VCV and PCV were effective in treating patients with acute COPD exacerbation, but PCV was associated with lower peak airway pressures and a significant decrease in barotrauma, indicating that it might be a safer ventilation method for this group of patients. This study compared the efficacy and safety of VCV and PCV in patients with acute COPD exacerbation and respiratory failure. Volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) are two common modes of mechanical ventilation with different advantages and disadvantages. ![]() Core Tip: Mechanical ventilation is a life-saving intervention for patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and respiratory failure.
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